One day, while on a delivery, Cloud is attacked by three unknown individuals, the leader of which is Kadaj, with Yazoo and Loz. Still burdened with the thoughts of Aeris' death, Cloud becomes more and more isolated from the rest of humanity and secludes himself.
Tifa Lockhart becomes the owner of a bar dubbed 7th Heaven. Mentally crippled in thoughts about failing to rescue the woman he had loved, Aeris (or Aerith) in the game, Cloud becomes a delivery boy for his own company, Strife Delivery Service. The film introduces the main protagonist, Cloud Strife, two years after defeating Sephiroth. This mysterious disease makes many uncomfortably weak and drains them of their physical and mental power.
It is known that Jenova was a powerful being that attempted to take over the planet many centuries ago, and attempted to make the planet submit to its will.
Geostigma was caused at the end of the game by the infiltration of Jenova cells into the Lifestream that encircles the planet (Gaia). Two years after the events of the game ( Final Fantasy VII), a mysterious disease known as Geostigma begins infecting individuals around the world.